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In vitro - In vivo correlation in the development of oral drug formulation A screenshot of the last

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ContentslistsavailableatScienceDirectInternationalJournalofPharmaceuticsjournalhomepage:www.elsevier.com/locate/ijpharmMinireviewInvitro–Invivocorrelationinthedevelopmentoforaldrugformulation:AscreenshotofthelasttwodecadesMarceloGomesDavanço⁎,DanielRossiCampos,PatríciadeOliveiraCarvalhoUniversidadeSãoFrancisco,ProgramadePós-graduaçãoStrictoSensuemCiênciasdaSaúde,BragançaPaulista,SãoPaulo,BrazilARTICLEINFOKeywords:Invitro–invivocorrelationIVIVCOralformulationDevelopmentBiopharmaceuticsClassificationSystemDissolutionABSTRACTInvitro–invivocorrelation(IVIVC)allowspredictionoftheinvivoperformanceofapharmaceuticalproductbasedonitsinvitrodrugreleaseprofilesandcanbeusedtooptimizeformulations,setdissolutionlimits,reducethenumberofbioequivalencestudiesduringproductdevelopment,andfacilitatecertainregulatorydecisions.ThisreviewarticleaimedtoassesspaperspublishedinthelasttwodecadesregardingtheuseoftheIVIVCinthedevelopmentoforalformulations,todemonstratethescenariointhisarea,aswellastodescribethemaincharacteristicsoftheassessedstudies.AsystematicsearchofPubMedandWebofSciencedatabaseswascon-ductedtoretrievearticlesreportingtheuseoftheIVIVCintheoralformulationdevelopmentintheperiodfrom1998to2018.Thequalifiedstudieswereabstractedregardingdrugname,dosageform,BCSclass,invitroandinvivodata,levelofIVIVC,numberofformulations,presenceofthevalidationandpredictability.Thediscussionwassupportedbythesedata,whichallowedtoaddressbroadlystrengthsandweaknessesinthisarea.Moreover,alargedatabasehasbeendescr

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