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ER Stress Protein CHOP Mediates Insulin Resistance

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  • 2020-12-11 12:17:09
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ArticleERStressProteinCHOPMediatesInsulinResistancebyModulatingAdiposeTissueMacrophagePolarityGraphicalAbstractHighlightsdAhigh-fatdiet(HFD)upregulatesERstress-relatedprotein,CHOP,inadipocytesdCHOPdeficiencypreventsHFD-inducedinsulinresistancewithATMM2polarizationdM2polarizationinvolvesmoreeosinophilsandTh2cytokinesinWATofCHOP�/�micedBMTexperimentsshowrecipientCHOPtobethemajordeterminantofATMpolarityAuthorsToruSuzuki,JunhongGao,YasushiIshigaki,...,TetsuyaYamada,SeiichiOyadomari,HidekiKatagiriCorrespondencekatagiri@med.tohoku.ac.jpInBriefSuzukietal.reportthatCHOPdeficiencymaintainsATMM2polarization,therebypreventinginsulinresistanceduringobesitydevelopment.CHOPupregulationinadipocytesaltersmicro-environmentalconditionsinWAT,involvingsuppressionofTh2cytokineproduction,resultinginATMM1polarization.ThismolecularmechanismmaylinkadiposeERstresswithsystemicinsulinresistance.Suzukietal.,2017,CellReports18,2045–2057February21,2017ª2017TheAuthors.http://dx.doi.org/10.1016/j.celrep.2017.01.076

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