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An in vitro and in vivo study of the brain-targeting effects of an epidermal growth factor-functiona

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ContentslistsavailableatScienceDirectJournalofControlledReleasejournalhomepage:www.elsevier.com/locate/jconrelAninvitroandinvivostudyofthebrain-targetingeffectsofanepidermalgrowthfactor-functionalizedcholeratoxin-likechimericproteinHuafengHea,DanminLina,JiajieSuna,XianyingHea,TiantianWanga,YinglinFanga,YijunLiua,KaixiangFana,XinxinChena,HuahongHeb,XiangguangLia,BianshengJic,SuqingZhaoa,XiZhenga,KunZhanga,d,HuaqianWanga,⁎aSchoolofBiomedicalandPharmaceuticalSciences,GuangdongUniversityofTechnology,Guangzhou510006,ChinabGuangzhouInstituteForDrugControl,Guangzhou510160,China.cKeyLaboratoryofNaturalMedicineandImmuneEngineering,HenanUniversity,Kaifeng475001,ChinadSchoolofBiotechnologyandHealth,WuyiUniversity,Jiangmen529020,ChinaARTICLEINFOKeywords:IntranasaladministrationBraindeliveryCholeratoxin-likechimericproteinsEpidermalgrowthfactorFluorescenceABSTRACTThedevelopmentofneuroprotectivedrugshasproventobeextremelydifficultbecauseoftheblood-brainbarrier.Intranasaladministrationisthoughttotransportthedrugfromthenasalcavityalongtheolfactoryandtrigeminalnervestothebrain,thusbypassingtheblood-brainbarrier.However,macromolecularproteindrugshavelowdeliveryefficiencyviathisrouteingeneral.Wehypothesizedthataninnocuouscholeratoxin-likechimericproteincouldbetterenhancetheefficiencyofproteindeliverythroughtheintranasalroute.Totestthishypothesis,wedesignedanenhancedgreenfluorescentprotein(EGFP)chimeratoevaluatetheeffectofthecholeratoxin(CT)asacarrierfordrugdeliveryintothebrain.Then,theEGFPwasreplacedwi

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