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Cellulose membrane modified with LED209 as an antibacterial and

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  • 2020-12-10 17:09:07
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CarbohydratePolymers252(2021)117138Availableonline28September20200144-8617/©2020ElsevierLtd.Allrightsreserved.CellulosemembranemodifiedwithLED209asanantibacterialandanti-adhesionmaterialZongbaoZhoua,ZixuanDonga,LeiWangb,RijianSonga,NaibinMeia,TaoChena,LeiLuoa,QiangDinga,XiaoyingWanga,ShunqingTanga,*aBiomedicalEngineeringInstitute,JinanUniversity,Guangzhou,510632,PRChinabDepartmentofPharmacology,UtrechtInstituteforPharmaceuticalSciences,UtrechtUniversity,3568CG,Utrecht,theNetherlandsARTICLEINFOKeywords:SurfacemodificationLED209cellulosemembraneclickreactionanti-adhesionactivityEHECABSTRACTBacterialadhesioninfectioncausedbymedicalmaterialsinclinicalapplicationhasbecomeaseriousthreat,anditurgentlyneedsnewstrategiestodealwiththeseclinicalchallenges.Inthiswork,LED209,ahighlyselectivehistidinesensorkinaseinhibitorofGram-negativebacteria,wascovalentlyattachedoncellulosemembrane(CM)viaclickreaction.Thedataofcontactanglemeasurements,ATR-FTIRandX-rayphotoelectronspectroscopyconfirmedthesuccessfulsynthesisofLED-CM.Inaddition,theresultsofantibacterialactivityofthemembranesshownthatLED-CMexhibitedexcellentanti-adhesionabilitytoEnterohemorrhagicEscherichiacoli(EHEC),andsignificantlyreducedtheformationofbacterialbiofilm.Importantly,LED-CMwasabletorepresstheexpressionofvirulencegenesinEHEC.Furthermore,LED209-functionalizedcellulosemembraneindicatednocytotoxicitytomammaliancells.Hence,ourpresentworkdemonstratedthatCMmodifiedwithLED209possessedmarkedlyanti-adhesionactivityagainstEHEC,whichoff

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