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Is HE4 Superior over CA-125 in the Follow-up of Patients with Epithelial Ovarian Cancer

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  • 2020-12-12 15:51:27
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SendOrdersforReprintstoreprints@benthamscience.netCurrentDrugTargets,2020,21,000-0001MINIREVIEWARTICLE1389-4501/20$65.00+.00©2020BenthamSciencePublishersIsHE4SuperioroverCA-125intheFollow-upofPatientswithEpithelialOvarianCancer?KhalidElBairi1,2,*,SaidAfqir1,2,3andMariamAmrani4,51FacultyofMedicineandPharmacy,MohamedIstUniversity,Oujda,Morocco;2CancerBiomarkersWorkinggroup,MohamedIstUniversity,Oujda,Morocco;3DepartmentofMedicalOncology,MohamedVIUniversityHospital,Oujda,Morocco;4FacultyofMedicineandPharmacy,MohamedVUniversity,Rabat,Morocco;5DepartmentofAnatomicPa-thology,NationalInstituteofOncology,Rabat,Morocco Abstract:Notwithstandingimportantadvancesinthetreatmentofepithelialovariancancer(EOC),thisdiseaseisstillaleadingcauseofglobalhighmortalityfromgynecologicalmalignancies.Recur-renceinEOCisinevitableanditisresponsibleforpoorsurvivalrates.Thereisacriticalneedfornov-eleffectivebiomarkerswithimprovedaccuracycomparedtothestandardcarbohydrateantigen-125(CA-125)forfollow-up.Thehumanepididymisprotein4(HE4)isusedforearlydetectionofEOC(ROMAalgorithm)aswellasforpredictingoptimalcytoreductionafterneoadjuvantchemotherapyandsurvivaloutcomes.Notably,theemergingHE4isapromisingprognosticbiomarkerthathasdis-playedbetteraccuracyinvariousrecentstudiesfordetectingrecurrentdisease.Inthismini-review,wediscussedthepotentialofHE4asanaccuratepredictorofEOCrecurrence.ARTICLEHISTORYReceived:November05,2019Revised:March19,2020Accepted:March30,2020DOI:10.2174/1389450121666200425211732Keywords:HE4,prog

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